JAMA : the journal of the American Medical Association
-
Metformin and glyburide monotherapy are used as alternatives to insulin in managing gestational diabetes. Whether a sequential strategy of these oral agents results in noninferior perinatal outcomes compared with insulin alone is unknown. ⋯ Treatment of gestational diabetes with metformin and additional glyburide, if needed, did not meet criteria for noninferiority compared with insulin with respect to the proportion of infants born large for gestational age.
-
This article highlights key National Institutes of Health (NIH) programs, policies, and scientific advances that have informed and improved the health of women and describe the promise and potential of harnessing cutting-edge science and integrative approaches to advance women's health research. Policy updates combined with recent scientific and programmatic initiatives are intended to expand understanding of women's health, deliver diagnostics, and develop preventive approaches and novel therapies to meet critical health needs of contemporary women. ⋯ NIH's policies, programs, and research funding fill gaps in knowledge about the health of women. Their synergistic results generate evidence for data-driven decision-making and targeted interventions that will improve the health not just of women, but of all people.