JAMA : the journal of the American Medical Association
The most recent articles from:
JAMA
-
Comparative Study
Oral Antibiotics and Risk of Serious Cutaneous Adverse Drug Reactions.
Serious cutaneous adverse drug reactions (cADRs) are potentially life-threatening drug hypersensitivity reactions involving the skin and internal organs. Antibiotics are a recognized cause of these reactions, but no studies have compared relative risks across antibiotic classes. ⋯ Commonly prescribed oral antibiotics are associated with an increased risk of serious cADRs compared with macrolides, with sulfonamides and cephalosporins carrying the highest risk. Prescribers should preferentially use lower-risk antibiotics when clinically appropriate.