JAMA : the journal of the American Medical Association
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Randomized Controlled Trial Multicenter Study
Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment.
Most cognitive functions decline with age. Prior studies suggest that testosterone treatment may improve these functions. ⋯ Among older men with low testosterone and age-associated memory impairment, treatment with testosterone for 1 year compared with placebo was not associated with improved memory or other cognitive functions.
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Randomized Controlled Trial Multicenter Study Pragmatic Clinical Trial
Effect of Collaborative Care vs Usual Care on Depressive Symptoms in Older Adults With Subthreshold Depression: The CASPER Randomized Clinical Trial.
There is little evidence to guide management of depressive symptoms in older people. ⋯ Among older adults with subthreshold depression, collaborative care compared with usual care resulted in a statistically significant difference in depressive symptoms at 4-month follow-up, of uncertain clinical importance. Although differences persisted through 12 months, findings are limited by attrition, and further research is needed to assess longer-term efficacy.