JAMA : the journal of the American Medical Association
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Elderly persons and women were underrepresented in randomized controlled trials (RCTs) prior to 1990. Since then, efforts have been made to correct these biases, but their effect is unclear. ⋯ Attempts at making cardiovascular RCTs more inclusive appear to have had limited success; thus, women and elderly persons remain underrepresented in published trial literature relative to their disease prevalence. Because safety and efficacy can vary as a function of sex and age, these enrollment biases undermine efforts to provide evidence-based care to all cardiac patients.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial.
Whether venous catheterization at the femoral site is associated with an increased risk of complications compared with that at the subclavian site is debated. ⋯ Femoral venous catheterization is associated with a greater risk of infectious and thrombotic complications than subclavian catheterization in ICU patients.