JAMA : the journal of the American Medical Association
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Randomized Controlled Trial Clinical Trial
Comprehensive follow-up care and life-threatening illnesses among high-risk infants: A randomized controlled trial.
Inner-city high-risk infants often receive limited and fragmented care, a problem that may increase serious illness. ⋯ Comprehensive follow-up care by experienced caregivers can be highly effective in reducing life-threatening illness without increasing costs among high-risk inner-city infants. JAMA. 2000;284:2070-2076.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group.
Pramipexole and levodopa both ameliorate the motor symptoms of early Parkinson disease (PD), but no controlled studies have compared long-term outcomes after initiating dopaminergic therapy with pramipexole vs levodopa. ⋯ Fewer patients receiving initial treatment for PD with pramipexole developed dopaminergic motor complications than with levodopa therapy. Despite supplementation with open-label levodopa in both groups, the levodopa-treated group had a greater improvement in total UPDRS compared with the pramipexole group. JAMA. 2000;284:1931-1938.