JAMA : the journal of the American Medical Association
The most recent articles from:
JAMA
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Comparison of paroxetine and nortriptyline in depressed patients with ischemic heart disease.
Depression and ischemic heart disease often are comorbid conditions and, in patients who have had a myocardial infarction, the presence of depression is associated with increased mortality. Patients with heart disease need a safe and effective treatment for depression. ⋯ Paroxetine and nortriptyline are effective treatments for depressed patients with ischemic heart disease. Nortriptyline treatment was associated with a significantly higher rate of serious adverse cardiac events compared with paroxetine.