JAMA : the journal of the American Medical Association
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JAMA
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Meta Analysis
Benzodiazepines and zolpidem for chronic insomnia: a meta-analysis of treatment efficacy.
To evaluate the efficacy of benzodiazepines and zolpidem tartrate in chronic insomnia based on a quantitative review of literature. ⋯ Benzodiazepines and zolpidem produced reliable improvements in commonly measured parameters of sleep in patients with chronic insomnia. Relative to the chronic and recurring course of insomnia, both the limited duration of treatments studied and the lack of follow-up data from controlled trials represent challenges for developing evidence-based guidelines for the use of hypnotics in the management of chronic insomnia.