JAMA : the journal of the American Medical Association
The most recent articles from:
JAMA
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Multicenter Study
Parenteral ketorolac and risk of gastrointestinal and operative site bleeding. A postmarketing surveillance study.
To evaluate the risk of gastrointestinal and operative site bleeding associated with the use of parenteral ketorolac tromethamine. ⋯ The overall associations between ketorolac use and both gastrointestinal bleeding and operative site bleeding are small. However, the risk associated with the drug is larger and clinically important when ketorolac is used in higher doses, in older subjects, and for more than 5 days. Improving physicians' prescribing practices by limiting the dose and duration of ketorolac use, especially in the elderly, should enhance its overall risk-benefit balance.