JAMA : the journal of the American Medical Association
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JAMA
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Meta Analysis
Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature.
To quantify the efficacy of BCG vaccine against tuberculosis (TB). ⋯ On average, BCG vaccine significantly reduces the risk of TB by 50%. Protection is observed across many populations, study designs, and forms of TB. Age at vaccination did not enhance predictiveness of BCG efficacy. Protection against tuberculous death, meningitis, and disseminated disease is higher than for total TB cases, although this result may reflect reduced error in disease classification rather than greater BCG efficacy.