JAMA : the journal of the American Medical Association
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomized comparative trial and cost analysis of 3-day antimicrobial regimens for treatment of acute cystitis in women.
To determine the efficacy, safety, and costs associated with four different 3-day regimens for the treatment of acute uncomplicated cystitis in women. ⋯ A 3-day regimen of trimethoprim-sulfamethoxazole is more effective and less expensive than 3-day regimens of nitrofurantoin, cefadroxil, or amoxicillin for treatment of uncomplicated cystitis in women. The increased efficacy of trimethoprim-sulfamethoxazole is likely related to its antimicrobial effects against E coli in the rectum, urethra, and vagina.
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The Instructions for Authors in this issue of THE JOURNAL describe a new format to be used for consensus statements. The format is epitomized in a structured abstract but affects the text itself. This Editorial explains why we are making this change, tells why each item is important, gives specific instructions for implementation, and provides examples.
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To determine the extent of firearm training among gun owners, how gun owners currently store their weapons, and the relationship between gun training and gun storage. ⋯ It has been suggested that many homicide, suicide, and accidental firearm injuries might be prevented if ready access to lethal weapons was reduced, in part through appropriate storage of guns. Although increased training has been advocated as the prime method to improve gun storage practices, our results cast doubt on whether firearm training, at least as currently provided, will substantially reduce the inappropriate storage of firearms.