Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Dec 2004
Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells.
Celecoxib, a cyclooxygenase 2 inhibitor, has chemopreventive and therapeutic activities toward lung cancer and other epithelial malignancies. Celecoxib can induce apoptosis in various cancer cell lines through a mechanism that is independent of its cyclooxygenase 2 inhibitory activity but is otherwise largely uncharacterized. We investigated the mechanism of celecoxib-induced apoptosis further. ⋯ Celecoxib appears to induce apoptosis in human NSCLC through the extrinsic death receptor pathway.