Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Jul 2006
Multicenter StudyBody size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC).
Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. ⋯ Waist circumference and WHR, indicators of abdominal obesity, were strongly associated with colon cancer risk in men and women in this population. The association of abdominal obesity with colon cancer risk may vary depending on HRT use in postmenopausal women; however, these findings require confirmation in future studies.