Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Mar 2007
Multicenter StudyLong-term risk of cardiovascular disease in 10-year survivors of breast cancer.
Radiotherapy for breast cancer as delivered in the 1970s has been associated with increased risk of cardiovascular disease, but recent studies of associations with modern regimens have been inconclusive. Few data on long-term cardiovascular disease risk according to specific radiation fields are available, and interaction with known cardiovascular risk factors has not been examined. ⋯ Radiotherapy as administered from the 1980s onward is associated with an increased risk of cardiovascular disease. Irradiated breast cancer patients should be advised to refrain from smoking to reduce their risk for cardiovascular disease.
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J. Natl. Cancer Inst. · Mar 2007
Longitudinal measurement of clinical mammographic breast density to improve estimation of breast cancer risk.
Whether a change over time in clinically measured mammographic breast density influences breast cancer risk is unknown. ⋯ An increase in BI-RADS breast density category within 3 years may be associated with an increase in breast cancer risk and a decrease in density category with a decrease in risk compared to breast cancer risk in women in whom breast density category remains unchanged. Two longitudinal measures of BI-RADS breast density may better predict a woman's risk of breast cancer than a single measure.