Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Jul 2009
Meta AnalysisRacial disparities in cancer survival among randomized clinical trials patients of the Southwest Oncology Group.
Racial disparities in cancer outcomes have been observed in several malignancies. However, it is unclear if survival differences persist after adjusting for clinical, demographic, and treatment variables. Our objective was to determine whether racial disparities in survival exist among patients enrolled in consecutive trials conducted by the Southwest Oncology Group (SWOG). ⋯ African American patients with sex-specific cancers had worse survival than white patients, despite enrollment on phase III SWOG trials with uniform stage, treatment, and follow-up.
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J. Natl. Cancer Inst. · Jul 2009
Editorial CommentIs race really a negative prognostic factor for cancer?
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J. Natl. Cancer Inst. · Jul 2009
Comparative StudyValue of adding single-nucleotide polymorphism genotypes to a breast cancer risk model.
Adding genotypes from seven single-nucleotide polymorphisms (SNPs), which had previously been associated with breast cancer, to the National Cancer Institute's Breast Cancer Risk Assessment Tool (BCRAT) increases the area under the receiver operating characteristic curve from 0.607 to 0.632. ⋯ The gains from BCRATplus7 are small in the applications examined. Models with SNPs, such as BCRATplus7, have not been validated for calibration in independent cohort data. Additional studies are needed to validate a model with SNPs and justify its use.