Journal of neurosurgery
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Journal of neurosurgery · Feb 2002
Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products.
The mechanisms involved in brain edema formation following intracerebral hemorrhage (ICH) have not been fully elucidated. The authors have found that red blood cell lysis plays an important role in edema development after ICH. In the present study, they sought to determine whether degradation products of hemoglobin cause brain edema. ⋯ Hemoglobin causes brain edema, at least in part, through its degradation products. Limiting hemoglobin degradation coupled with the use of iron chelators may be a novel therapeutic approach to limit brain edema after ICH.
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Journal of neurosurgery · Feb 2002
Evaluation of the healing process after dural reconstruction achieved using a free fascial graft.
This study was undertaken to investigate the healing process and to delineate factors important for the survival of free fascial grafts used for dural repair. ⋯ Fascial grafts tolerated extraordinary intracranial pressures at 1 week postoperatively. Free fascial grafts can heal with durable fibrous tissue without the presence of a blood supply from an overlying vascularized flap.