Annals of the New York Academy of Sciences
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Ann. N. Y. Acad. Sci. · Nov 2000
Global strategies for the prevention of HIV transmission from mothers to infants.
The first part of this paper provides a brief overview of the global situation, the second will describe several scenarios that capture the key features of the emerging epidemics, and the third will present the specific challenges that these scenarios pose to us in terms of preventing the further spread of HIV.
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Ann. N. Y. Acad. Sci. · Sep 2000
Comparative Study Clinical TrialIbogaine: complex pharmacokinetics, concerns for safety, and preliminary efficacy measures.
Ibogaine is an indole alkaloid found in the roots of Tabernanthe Iboga (Apocynaceae family), a rain forest shrub that is native to western Africa. Ibogaine is used by indigenous peoples in low doses to combat fatigue, hunger and thirst, and in higher doses as a sacrament in religious rituals. Members of American and European addict self-help groups have claimed that ibogaine promotes long-term drug abstinence from addictive substances, including psychostimulants and opiates. ⋯ We report here that ibogaine significantly decreased craving for cocaine and heroin during inpatient detoxification. Self-reports of depressive symptoms were also significantly lower after ibogaine treatment and at 30 days after program discharge. Because ibogaine is cleared rapidly from the blood, the beneficial aftereffects of the drug on craving and depressed mood may be related to the effects of noribogaine on the central nervous system.