Annals of the New York Academy of Sciences
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Ann. N. Y. Acad. Sci. · Oct 1999
Study on the distribution pattern of skin temperature in normal Chinese and detection of the depth of early burn wound by infrared thermography.
Conduct basic research of the distribution pattern of skin temperature and estimate the wound depth in normal Chinese in the early stage of burn injury by using technical thermography. ⋯ The depth of early burn wound can be detected by using infrared thermography, which is an objective, fast, non-touching, and noninvasive method.
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A total of 211 patients were admitted at the UP-PGH Burn Unit in 1995. Sixty-eight (32.2%) patients suffered burn injuries secondary to electrical injury. In the period from July to December 1995, a total of 28 patients were admitted because of burns caused by electricity. ⋯ A total of 22 operations were performed on 28 patients, including 7 extremity amputations, which makes an amputation rate of 25%. There were 5 deaths secondary to overwhelming wound sepsis, making an overall mortality rate of 21.7% and an operative mortality rate of 22.7%. The average length of hospital stay was 17.2 days.
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Ann. N. Y. Acad. Sci. · Jun 1999
A chemically modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats.
Estrogen deficiency in the postmenopausal (PM) female is the major cause of osteoporosis and may contribute to increased periodontal disease, including alveolar bone loss, seen in these women. In the current study, an animal model of PM osteoporosis, the OVX adult female rat, was studied to determine: (i) the relationship between periodontal breakdown and skeletal bone loss, and (ii) the effect of CMT-8 on gingival collagenase and bone loss. OVX rats were daily gavaged with CMT-8 (1, 2, or 5 mg/rat) for 28 or 90 days; non-OVX rats and those gavaged with vehicle alone served as controls. ⋯ Western blot revealed a similar pattern for MMP-8 and MMP-13 concentrations. The changes in the gingival collagenase activity paralleled changes in periodontal bone loss, which, in turn, reflected trabecular bone density changes. Preliminary studies on PM humans administered sub-antimicrobial tetracycline as a matrix metalloproteinase inhibitor are under way.