Annals of the New York Academy of Sciences
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Ann. N. Y. Acad. Sci. · Jan 1986
ReviewAltered pain and visual sensitivity in humans: the effects of acute and chronic stress.
In the runner study, as measured by tourniquet ischemic pain, exercise stress produced hypoalgesia 20 minutes post-run, followed by hyperalgesia and euphoria at 30 minutes. The hypoalgesia and euphoria were reversed by naloxone. Exercise stress also produced a decrease in P(A), suggesting hypoalgesia to the thermal cutaneous stimulation. ⋯ Again, in contrast to the acute experimental pain studies, the emotional stress of mental illness produces hypoalgesia, but not anesthesia. Finally, the somatosensory system is not the only the sensory system affected by stress. Cold-pressor pain decreases visual sensitivity both during and for a few minutes following stimulation, and does not interfere with short-term (supra-digit span) memory.
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Ann. N. Y. Acad. Sci. · Jan 1985
Opiate antagonistic function of cholecystokinin in analgesia and energy balance systems.
Because several effects of cholecystokinin (CCK) are opposite to those reported for opioids, it seemed likely that CCK may function as an endogenous antagonist of opiate action. This hypothesis was tested initially by assessing the effect of CCK on opiate analgesias. Systemic administration of CCK attenuated opiate analgesias produced by morphine and footshock, but did not reduce nonopiate footshock analgesia. ⋯ In immunohistochemical studies, we have found a dense CCK fiber plexus in the dorsal PVN, a critical site for opiate-induced feeding. Direct microinjections of CCK to this region reduced short-term food intake by 28%. The findings presented here support the hypothesis that an opiate antagonistic function of CCK may account for several previously reported effects of this peptide.