European urology
-
Review Practice Guideline
EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction.
To present a summary of the 2013 version of the European Association of Urology guidelines on the treatment and follow-up of male lower urinary tract symptoms (LUTS). ⋯ These symptom-oriented guidelines provide practical guidance for the management of men experiencing LUTS. The full version is available online (www.uroweb.org/gls/pdf/12_Male_LUTS.pdf).
-
Multicenter Study Comparative Study
Retrospective comparison of triple-sequence therapies in metastatic renal cell carcinoma.
The optimal sequence of targeted therapy in patients with metastatic renal cell carcinoma (mRCC) has not been defined. ⋯ The sequence therapies VEGFi-mTORi-rTKI and VEGFi-rTKI-mTORi with the currently available agents appear to be equally efficacious in terms of PFS, OS, and response rate, with no apparent beneficial effect with an early use of mTORi.
-
Comparative Study
Temporal trends, practice patterns, and treatment outcomes for infected upper urinary tract stones in the United States.
The incidence of infected urolithiasis is unknown, and evidence describing the optimal management strategy for obstruction is equivocal. ⋯ Between 1999 and 2009, women were twice as likely to have infected urolithiasis. Rates of associated sepsis and severe sepsis increased, but mortality rates remained stable. Analysis of competing treatment strategies for immediate decompression demonstrates decreasing utilization of PCN, which showed higher rates of adverse outcomes. These findings should be viewed as preliminary and hypothesis generating, demonstrating the pressing need for further study.