The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Clinical Trial
Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults.
Tuberculous meningitis kills or disables more than half of those affected with the disease. Previous studies have been too small to determine whether adjunctive treatment with corticosteroids can reduce the risk of disability or death among adults with tuberculous meningitis, and the effect of coinfection with the human immunodeficiency virus (HIV) is unclear. ⋯ Adjunctive treatment with dexamethasone improves survival in patients over 14 years of age with tuberculous meningitis but probably does not prevent severe disability.
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Historical Article
Failing the public health--rofecoxib, Merck, and the FDA.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Preoperative versus postoperative chemoradiotherapy for rectal cancer.
Postoperative chemoradiotherapy is the recommended standard therapy for patients with locally advanced rectal cancer. In recent years, encouraging results with preoperative radiotherapy have been reported. We compared preoperative chemoradiotherapy with postoperative chemoradiotherapy for locally advanced rectal cancer. ⋯ Preoperative chemoradiotherapy, as compared with postoperative chemoradiotherapy, improved local control and was associated with reduced toxicity but did not improve overall survival.