The New England journal of medicine
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Randomized Controlled Trial Clinical Trial
Mass treatment to eliminate filariasis in Papua New Guinea.
The global initiative to eradicate bancroftian filariasis currently relies on mass treatment with four to six annual doses of antifilarial drugs. The goal is to reduce the reservoir of microfilariae in the blood to a level that is insufficient to maintain transmission by the mosquito vector. ⋯ Annual mass treatment with drugs such as diethylcarbamazine can virtually eliminate the reservoir of microfilariae and greatly reduce the frequency of clinical lymphatic abnormalities due to bancroftian filariasis. Eradication may be possible in areas with moderate rates of transmission, but longer periods of treatment or additional control measures may be necessary in areas with high rates of transmission.
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Comment Letter Case Reports
Organ transplantation in HIV-infected patients.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus.
Controversy exists about the best surgical treatment for esophageal carcinoma. ⋯ Transhiatal esophagectomy was associated with lower morbidity than transthoracic esophagectomy with extended en bloc lymphadenectomy. Although median overall, disease-free, and quality-adjusted survival did not differ statistically between the groups, there was a trend toward improved long-term survival at five years with the extended transthoracic approach.