The New England journal of medicine
The most recent articles from:
N. Engl. J. Med.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Effects of estrogen replacement on the progression of coronary-artery atherosclerosis.
Heart disease is a major cause of illness and death in women. To understand better the role of estrogen in the treatment and prevention of heart disease, more information is needed about its effects on coronary atherosclerosis and the extent to which concomitant progestin therapy may modify these effects. ⋯ Neither estrogen alone nor estrogen plus medroxyprogesterone acetate affected the progression of coronary atherosclerosis in women with established disease. These results suggest that such women should not use estrogen replacement with an expectation of cardiovascular benefit.