The New England journal of medicine
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Comment Letter
Tranexamic acid in hereditary hemorrhagic telangiectasia.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma glucose concentrations in the fasting state and after an oral glucose load, overweight, and a sedentary lifestyle--are potentially reversible. We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes. ⋯ Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk. The lifestyle intervention was more effective than metformin.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Benefit of atrial pacing in sleep apnea syndrome.
Many patients with sleep apnea syndrome have nocturnal bradycardia, paroxysmal tachyarrhythmias, or both, which can be prevented by permanent atrial pacing. We evaluated the effect of using cardiac pacing to increase the heart rate during sleep in patients with sleep apnea syndrome. ⋯ In patients with sleep apnea syndrome, atrial overdrive pacing significantly reduces the number of episodes of central or obstructive sleep apnea without reducing the total sleep time.