The New England journal of medicine
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Comment Randomized Controlled Trial Clinical Trial
The effect of fecal occult-blood screening on the incidence of colorectal cancer.
Both annual testing for fecal occult blood and biennial testing significantly reduce mortality from colorectal cancer. However, the effect of screening on the incidence of colorectal cancer remains uncertain, despite the diagnosis and removal of precancerous lesions in many persons who undergo screening. ⋯ The use of either annual or biennial fecal occult-blood testing significantly reduces the incidence of colorectal cancer.
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Conflicts of interest pose a threat to the integrity of scientific research. The current regulations of the U.S. Public Health Service and the National Science Foundation require that medical schools and other research institutions report the existence of conflicts of interest to the funding agency but allow the institutions to manage conflicts internally. The regulations do not specify how to do so. ⋯ There is substantial variation among policies on conflicts of interest at medical schools and other research institutions. This variation, combined with the fact that many scientific journals and funding agencies do not require disclosure of conflicts of interest, suggests that the current standards may not be adequate to maintain a high level of scientific integrity.
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Historical Article
In whose best interest? Breaching the academic-industrial wall.