The New England journal of medicine
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Editorial Comment
Particulate air pollution and mortality--clearing the air.
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There is substantial concern that financial conflicts of interest on the part of investigators conducting clinical trials may compromise the well-being of research subjects. ⋯ Policies governing conflicts of interest at leading medical schools in the United States vary widely. We suggest that university-based investigators and research staff be prohibited from holding stock, stock options, or decision-making positions in a company that may reasonably appear to be affected by the results of their clinical research. Of the 10 medical schools we studied, only 1 had a policy that was close to this standard.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis.
Etanercept, which blocks the action of tumor necrosis factor, reduces disease activity in patients with long-standing rheumatoid arthritis. Its efficacy in reducing disease activity and preventing joint damage in patients with active early rheumatoid arthritis is unknown. ⋯ As compared with oral methotrexate, subcutaneous [corrected] etanercept acted more rapidly to decrease symptoms and slow joint damage in patients with early active rheumatoid arthritis.
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Comment Randomized Controlled Trial Clinical Trial
The effect of fecal occult-blood screening on the incidence of colorectal cancer.
Both annual testing for fecal occult blood and biennial testing significantly reduce mortality from colorectal cancer. However, the effect of screening on the incidence of colorectal cancer remains uncertain, despite the diagnosis and removal of precancerous lesions in many persons who undergo screening. ⋯ The use of either annual or biennial fecal occult-blood testing significantly reduces the incidence of colorectal cancer.