The New England journal of medicine
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Clinical Trial Controlled Clinical Trial
Entrainment of free-running circadian rhythms by melatonin in blind people.
Most totally blind people have circadian rhythms that are "free-running" (i.e., that are not synchronized to environmental time cues and that oscillate on a cycle slightly longer than 24 hours). This condition causes recurrent insomnia and daytime sleepiness when the rhythms drift out of phase with the normal 24-hour cycle. We investigated whether a daily dose of melatonin could entrain their circadian rhythms to a normal 24-hour cycle. ⋯ Administration of melatonin can entrain circadian rhythms in most blind people who have free-running rhythms.
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Clinical Trial Controlled Clinical Trial
Effect of long-term treatment with inhaled budesonide on adult height in children with asthma.
Short-term studies have shown that inhaled corticosteroids may reduce the growth of children with asthma. However, the effect of long-term treatment on adult height is uncertain. ⋯ Children with asthma who have received long-term treatment with budesonide attain normal adult height.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group.
Antiinflammatory therapies, such as inhaled corticosteroids or nedocromil, are recommended for children with asthma, although there is limited information on their long-term use. ⋯ In children with mild-to-moderate asthma, neither budesonide nor nedocromil is better than placebo in terms of lung function, but inhaled budesonide improves airway responsiveness and provides better control of asthma than placebo or nedocromil. The side effects of budesonide are limited to a small, transient reduction in growth velocity.