The New England journal of medicine
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Randomized Controlled Trial Clinical Trial
The effect of calcium supplementation on bone density during lactation and after weaning.
Women may lose bone during lactation because of calcium lost in breast milk. We studied whether calcium supplementation prevents bone loss during lactation or augments bone gain after weaning. ⋯ Calcium supplementation does not prevent bone loss during lactation and only slightly enhances the gain in bone density after weaning.
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Comparative Study
Discrepancies between meta-analyses and subsequent large randomized, controlled trials.
Meta-analyses are now widely used to provide evidence to support clinical strategies. However, large randomized, controlled trials are considered the gold standard in evaluating the efficacy of clinical interventions. ⋯ The outcomes of the 12 large randomized, controlled trials that we studied were not predicted accurately 35 percent of the time by the meta-analyses published previously on the same topics.