The New England journal of medicine
The most recent articles from:
N. Engl. J. Med.
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Comment Letter
Intravenous immune globulin to reduce nosocomial infections.
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Multicenter Study
Survival in medically treated patients with homozygous beta-thalassemia.
The prognosis of patients with homozygous beta-thalassemia (thalassemia major) has been improved by transfusion and iron-chelation therapy. We analyzed outcome and prognostic factors among patients receiving transfusions and chelation therapy who had reached the age at which iron-induced cardiac disease, the most common cause of death, usually occurs. ⋯ The prognosis for survival without cardiac disease is excellent for patients with thalassemia major who receive regular transfusions and whose serum ferritin concentrations remain below 2500 ng per milliliter with chelation therapy.