The New England journal of medicine
The most recent articles from:
N. Engl. J. Med.
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Comment Letter
Idiopathic hyperplasia of pulmonary neuroendocrine cells.
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Comparative Study Clinical Trial
Inhaled nitric oxide for the adult respiratory distress syndrome.
The adult respiratory distress syndrome is characterized by pulmonary hypertension and right-to-left shunting of venous blood. We investigated whether inhaling nitric oxide gas would cause selective vasodilation of ventilated lung regions, thereby reducing pulmonary hypertension and improving gas exchange. ⋯ Inhalation of nitric oxide by patients with severe adult respiratory distress syndrome reduces the pulmonary-artery pressure and increases arterial oxygenation by improving the matching of ventilation with perfusion, without producing systemic vasodilation. Randomized, blinded trials will be required to determine whether inhaled nitric oxide will improve outcome.