The New England journal of medicine
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N. Engl. J. Med.
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Randomized Controlled Trial Clinical Trial
Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia.
The pathophysiologic aspects of pruritus in patients with chronic renal insufficiency are poorly understood, and there is no universally effective treatment. The improvement of pruritus in several patients receiving erythropoietin therapy raised the possibility that erythropoietin affects uremic pruritus directly. ⋯ Erythropoietin therapy lowers plasma histamine concentrations in patients with uremia and can result in marked improvement of pruritus.