The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Clinical Trial
Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.
Patients with congestive heart failure have a high mortality rate and are also hospitalized frequently. We studied the effect of an angiotensin-converting-enzyme inhibitor, enalapril, on mortality and hospitalization in patients with chronic heart failure and ejection fractions less than or equal to 0.35. ⋯ The addition of enalapril to conventional therapy significantly reduced mortality and hospitalizations for heart failure in patients with chronic congestive heart failure and reduced ejection fractions.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Treatment of acute cluster headache with sumatriptan.
Attacks of cluster headache are difficult to treat. Sumatriptan, an agonist of 5-hydroxytryptamine1-like receptors, has proved effective in the treatment of migraine. The clinical similarities between migraine and cluster headache and positive results from an open pilot study in patients with cluster headache indicated that sumatriptan should be evaluated more rigorously in the treatment of this condition. ⋯ Sumatriptan is an effective and well-tolerated treatment for acute attacks of cluster headache.