The New England journal of medicine
-
Randomized Controlled Trial Clinical Trial
Lack of effect of intraarticular corticosteroids for chronic pain in the cervical zygapophyseal joints.
Chronic pain in the cervical zygapophyseal joints is a common problem after a whiplash injury. Treatment with intraarticular injections of corticosteroid preparations has been advocated, but the value of this approach has not been established. We compared the efficacy of a depot injection of a corticosteroid preparation with the efficacy of an injection of a local anesthetic agent in patients with painful cervical zygapophyseal joints. ⋯ Intraarticular injection of betamethasone is not effective therapy for pain in the cervical zygapophyseal joints after a whiplash injury.
-
Comment Letter Case Reports
Tumor lysis syndrome after treatment of chronic lymphocytic leukemia with cladribine.
-
Randomized Controlled Trial Clinical Trial
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers.
Epidemiologic evidence indicates that diets high in carotenoid-rich fruits and vegetables, as well as high serum levels of vitamin E (alpha-tocopherol) and beta carotene, are associated with a reduced risk of lung cancer. ⋯ We found no reduction in the incidence of lung cancer among male smokers after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene. In fact, this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.