The New England journal of medicine

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• N. Engl. J. Med. · Mar 1999

  Clinical Trial

  Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group.

  Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death. The standard treatment is inhibition of alcohol dehydrogenase with ethanol, given in intoxicating doses, and adjunctive hemodialysis. We studied the efficacy of fomepizole, a new inhibitor of alcohol dehydrogenase, in the treatment of ethylene glycol poisoning. ⋯ In patients with ethylene glycol poisoning, fomepizole administered early in the course of intoxication prevents renal injury by inhibiting the formation of toxic metabolites.

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• N. Engl. J. Med. · Mar 1999

  Review

  Treatment of attention-deficit-hyperactivity disorder.

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• N. Engl. J. Med. · Mar 1999

  Is informed consent always necessary for randomized, controlled trials? .

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• N. Engl. J. Med. · Mar 1999

  Biography Historical Article

  Images in clinical medicine. Endoscopy in its infancy.

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• N. Engl. J. Med. · Mar 1999

  Correction: Case Records of the Massachusetts General Hospital (Case 3-1999).

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