The New England journal of medicine
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Clinical Trial Controlled Clinical Trial
Entrainment of free-running circadian rhythms by melatonin in blind people.
Most totally blind people have circadian rhythms that are "free-running" (i.e., that are not synchronized to environmental time cues and that oscillate on a cycle slightly longer than 24 hours). This condition causes recurrent insomnia and daytime sleepiness when the rhythms drift out of phase with the normal 24-hour cycle. We investigated whether a daily dose of melatonin could entrain their circadian rhythms to a normal 24-hour cycle. ⋯ Administration of melatonin can entrain circadian rhythms in most blind people who have free-running rhythms.
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Clinical Trial Controlled Clinical Trial
Effect of long-term treatment with inhaled budesonide on adult height in children with asthma.
Short-term studies have shown that inhaled corticosteroids may reduce the growth of children with asthma. However, the effect of long-term treatment on adult height is uncertain. ⋯ Children with asthma who have received long-term treatment with budesonide attain normal adult height.