The New England journal of medicine
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A monoclonal gammopathy of undetermined significance (MGUS) occurs in up to 2 percent of persons 50 years of age or older. Reliable predictors of progression have not been identified, and information on prognosis is limited. ⋯ The risk of progression of MGUS to multiple myeloma or related disorders is about 1 percent per year.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Use of a Staphylococcus aureus conjugate vaccine in patients receiving hemodialysis.
In patients with decreased resistance to infection, Staphylococcus aureus is a major cause of bacteremia and its complications. The capsular polysaccharides are essential for the pathogenesis of and immunity to S. aureus infection and are targets for vaccines. ⋯ In patients receiving hemodialysis, a conjugate vaccine can confer partial immunity against S. aureus bacteremia for approximately 40 weeks, after which protection wanes as antibody levels decrease.