The New England journal of medicine
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Comparative Study
The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization.
It is not known whether infants conceived with use of intracytoplasmic sperm injection or in vitro fertilization have a higher risk of birth defects than infants conceived naturally. ⋯ Infants conceived with use of intracytoplasmic sperm injection or in vitro fertilization have twice as high a risk of a major birth defect as naturally conceived infants.