The New England journal of medicine
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Randomized Controlled Trial Clinical Trial
Primary chemoprevention of familial adenomatous polyposis with sulindac.
Familial adenomatous polyposis is caused by a germ-line mutation in the adenomatous polyposis coli gene and is characterized by the development of hundreds of colorectal adenomas and, eventually, colorectal cancer. Nonsteroidal antiinflammatory drugs can cause regression of adenomas, but whether they can prevent adenomas is unknown. ⋯ Standard doses of sulindac did not prevent the development of adenomas in subjects with familial adenomatous polyposis.