The New England journal of medicine
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Randomized Controlled Trial Clinical Trial
Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus.
Cardiovascular disease causes severe morbidity and mortality in type 1 diabetes, although the specific risk factors and whether chronic hyperglycemia has a role are unknown. We examined the progression of carotid intima-media thickness, a measure of atherosclerosis, in a population with type 1 diabetes. ⋯ Intensive therapy during the DCCT resulted in decreased progression of intima-media thickness six years after the end of the trial.