The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Clinical Trial
Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer.
We determined the effect of breast irradiation plus tamoxifen on disease-free survival and local relapse in women 50 years of age or older who had T1 or T2 node-negative breast cancer. ⋯ As compared with tamoxifen alone, radiotherapy plus tamoxifen significantly reduces the risk of breast and axillary recurrence after lumpectomy in women with small, node-negative, hormone-receptor-positive breast cancers.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer.
In women 70 years of age or older who have early breast cancer, it is unclear whether lumpectomy plus tamoxifen is as effective as lumpectomy followed by tamoxifen plus radiation therapy. ⋯ Lumpectomy plus adjuvant therapy with tamoxifen alone is a realistic choice for the treatment of women 70 years of age or older who have early, estrogen-receptor-positive breast cancer.