The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation.
During the administration of advanced cardiac life support for resuscitation from cardiac arrest, a combination of vasopressin and epinephrine may be more effective than epinephrine or vasopressin alone, but evidence is insufficient to make clinical recommendations. ⋯ As compared with epinephrine alone, the combination of vasopressin and epinephrine during advanced cardiac life support for out-of-hospital cardiac arrest does not improve outcome. (ClinicalTrials.gov number, NCT00127907.)
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Randomized Controlled Trial Multicenter Study
Intensity of renal support in critically ill patients with acute kidney injury.
The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial. ⋯ Intensive renal support in critically ill patients with acute kidney injury did not decrease mortality, improve recovery of kidney function, or reduce the rate of nonrenal organ failure as compared with less-intensive therapy involving a defined dose of intermittent hemodialysis three times per week and continuous renal-replacement therapy at 20 ml per kilogram per hour. (ClinicalTrials.gov number, NCT00076219.)