The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy.
The benefits of endoscopic testing for colorectal-cancer screening are uncertain. We evaluated the effect of screening with flexible sigmoidoscopy on colorectal-cancer incidence and mortality. ⋯ Screening with flexible sigmoidoscopy was associated with a significant decrease in colorectal-cancer incidence (in both the distal and proximal colon) and mortality (distal colon only). (Funded by the National Cancer Institute; PLCO ClinicalTrials.gov number, NCT00002540.).
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Comment Letter
Effect of a monoclonal antibody to PCSK9 on LDL cholesterol.