The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Comparison of pregabalin with pramipexole for restless legs syndrome.
Dopaminergic medications relieve symptoms of the restless legs syndrome (RLS) but have the potential to cause iatrogenic worsening (augmentation) of RLS with long-term treatment. Pregabalin may be an effective alternative. ⋯ Pregabalin provided significantly improved treatment outcomes as compared with placebo, and augmentation rates were significantly lower with pregabalin than with 0.5 mg of pramipexole. (Funded by Pfizer; ClinicalTrials.gov number, NCT00806026.).
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A 59-year-old man was admitted to this hospital because of fever, confusion, rash, thrombocytopenia, and renal failure, 10 days after a hunting trip in the Nevada valley. Diagnostic procedures were performed, and diagnostic test results were received from another hospital.
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More than 40 medical specialties have identified "Choosing Wisely" lists of five overused or low-value services. But these services vary widely in potential impact on care and spending, and specialty societies often name other specialties' services as low value.
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Case Reports Interactive Tutorial
Interactive medical case: wasting away.
This interactive feature presents the case of a 40-year-old woman with pain, weakness, and poor oral intake. She had had a gradual onset of bilateral flank pain spreading to her lower back, abdomen, and extremities. Test your diagnostic and therapeutic skills at NEJM.org.
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Despite knowing that heart disease kills more women each year than all cancers combined, most women fear breast cancer far more - and their health-related behavior reflects this difference. If our sense of risk is less about fact than about feeling, how do we adjust it?