The New England journal of medicine
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Autism involves early brain overgrowth and dysfunction, which is most strongly evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons in the prefrontal cortex among children with autism signals a disturbance in prenatal development and may be concomitant with abnormal cell type and laminar development. ⋯ In this small, explorative study, we found focal disruption of cortical laminar architecture in the cortexes of a majority of young children with autism. Our data support a probable dysregulation of layer formation and layer-specific neuronal differentiation at prenatal developmental stages. (Funded by the Simons Foundation and others.).
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Editorial Comment
Overcoming drug resistance in ALK-rearranged lung cancer.
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Letter Clinical Trial
Ofatumumab for rituximab-resistant nephrotic syndrome.