The New England journal of medicine
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Comment Letter
Sofosbuvir and Velpatasvir for Patients with HCV Infection.
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Randomized Controlled Trial Multicenter Study Comparative Study
Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma.
Ixazomib is an oral proteasome inhibitor that is currently being studied for the treatment of multiple myeloma. ⋯ The addition of ixazomib to a regimen of lenalidomide and dexamethasone was associated with significantly longer progression-free survival; the additional toxic effects with this all-oral regimen were limited. (Funded by Millennium Pharmaceuticals; TOURMALINE-MM1 ClinicalTrials.gov number, NCT01564537.).
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The West African outbreak of Ebola virus disease that peaked in 2014 has caused more than 11,000 deaths. The development of an effective Ebola vaccine is a priority for control of a future outbreak. ⋯ The ChAd3 vaccine boosted with MVA elicited B-cell and T-cell immune responses to ZEBOV that were superior to those induced by the ChAd3 vaccine alone. (Funded by the Wellcome Trust and others; ClinicalTrials.gov number, NCT02240875.).