The New England journal of medicine
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Comment Letter
Health Effects of Overweight and Obesity in 195 Countries.
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Editorial Comment
We Can Do Better - Improving Outcomes in the Midst of an Emergency.
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Randomized Controlled Trial Multicenter Study Comparative Study
Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis.
Romosozumab is a monoclonal antibody that binds to and inhibits sclerostin, increases bone formation, and decreases bone resorption. ⋯ In postmenopausal women with osteoporosis who were at high risk for fracture, romosozumab treatment for 12 months followed by alendronate resulted in a significantly lower risk of fracture than alendronate alone. (Funded by Amgen and others; ARCH ClinicalTrials.gov number, NCT01631214 .).
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Randomized Controlled Trial Comparative Study
Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia.
The safety and efficacy of vaccines to prevent Ebola virus disease (EVD) were unknown when the incidence of EVD was peaking in Liberia. ⋯ A randomized, placebo-controlled phase 2 trial of two vaccines that was rapidly initiated and completed in Liberia showed the capability of conducting rigorous research during an outbreak. By 1 month after vaccination, the vaccines had elicited immune responses that were largely maintained through 12 months. (Funded by the National Institutes of Allergy and Infectious Diseases and the Liberian Ministry of Health; PREVAIL I ClinicalTrials.gov number, NCT02344407 .).