The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine.
Which medication, if any, to use to prevent the headache of pediatric migraine has not been established. ⋯ There were no significant differences in reduction in headache frequency or headache-related disability in childhood and adolescent migraine with amitriptyline, topiramate, or placebo over a period of 24 weeks. The active drugs were associated with higher rates of adverse events. (Funded by the National Institutes of Health; CHAMP ClinicalTrials.gov number, NCT01581281 ).
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Randomized Controlled Trial Multicenter Study Comparative Study
Phase 3 Trial of (177)Lu-Dotatate for Midgut Neuroendocrine Tumors.
Patients with advanced midgut neuroendocrine tumors who have had disease progression during first-line somatostatin analogue therapy have limited therapeutic options. This randomized, controlled trial evaluated the efficacy and safety of lutetium-177 (177Lu)-Dotatate in patients with advanced, progressive, somatostatin-receptor-positive midgut neuroendocrine tumors. ⋯ Treatment with 177Lu-Dotatate resulted in markedly longer progression-free survival and a significantly higher response rate than high-dose octreotide LAR among patients with advanced midgut neuroendocrine tumors. Preliminary evidence of an overall survival benefit was seen in an interim analysis; confirmation will be required in the planned final analysis. Clinically significant myelosuppression occurred in less than 10% of patients in the 177Lu-Dotatate group. (Funded by Advanced Accelerator Applications; NETTER-1 ClinicalTrials.gov number, NCT01578239 ; EudraCT number 2011-005049-11 .).
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Comment Letter
Adjunctive Azithromycin Prophylaxis for Cesarean Delivery.