The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.
Daily low-dose aspirin for primary prevention in the healthy elderly offers no cardiovascular benefit but does increase the risk of major hemorrhage.
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Randomized Controlled Trial Multicenter Study
Effect of Aspirin on Disability-free Survival in the Healthy Elderly.
Daily low-dose aspirin does not improve disability-free survival in the healthy elderly.
pearl -
Randomized Controlled Trial Multicenter Study
Effects of n-3 Fatty Acid Supplements in Diabetes Mellitus.
Increased intake of n-3 fatty acids has been associated with a reduced risk of cardiovascular disease in observational studies, but this finding has not been confirmed in randomized trials. It remains unclear whether n-3 (also called omega-3) fatty acid supplementation has cardiovascular benefit in patients with diabetes mellitus. ⋯ Among patients with diabetes without evidence of cardiovascular disease, there was no significant difference in the risk of serious vascular events between those who were assigned to receive n-3 fatty acid supplementation and those who were assigned to receive placebo. (Funded by the British Heart Foundation and others; Current Controlled Trials number, ISRCTN60635500 ; ClinicalTrials.gov number, NCT00135226 .).