The New England journal of medicine
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Randomized Controlled Trial
Phase 3 Efficacy Analysis of a Typhoid Conjugate Vaccine Trial in Nepal.
Salmonella Typhi is a major cause of fever in children in low- and middle-income countries. A typhoid conjugate vaccine (TCV) that was recently prequalified by the World Health Organization was shown to be efficacious in a human challenge model, but data from efficacy trials in areas where typhoid is endemic are lacking. ⋯ A single dose of TCV was immunogenic and effective in reducing S. Typhi bacteremia in children 9 months to 16 years of age. (Funded by the Bill and Melinda Gates Foundation; Current Controlled Trials number, ISRCTN43385161.).
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Editorial Comment
Parting the Clouds over Typhoid with a New Conjugate Vaccine.
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Comment Letter
Treatment of Hypertension in Patients with Asthma. Reply.