The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Immediate Transfusion in African Children with Uncomplicated Severe Anemia.
The World Health Organization recommends not performing transfusions in African children hospitalized for uncomplicated severe anemia (hemoglobin level of 4 to 6 g per deciliter and no signs of clinical severity). However, high mortality and readmission rates suggest that less restrictive transfusion strategies might improve outcomes. ⋯ There was no evidence of differences in clinical outcomes over 6 months between the children who received immediate transfusion and those who did not. The triggered-transfusion strategy in the control group resulted in lower blood use; however, the length of hospital stay was longer, and this strategy required clinical and hemoglobin monitoring. (Funded by the Medical Research Council and Department for International Development; TRACT Current Controlled Trials number, ISRCTN84086586.).
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Historical Article
Digital Futures Past - The Long Arc of Big Data in Medicine.
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Letter Case Reports
Phenotype in an Infant with SOD1 Homozygous Truncating Mutation.