The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis.
More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. ⋯ Among patients with severe ANCA-associated vasculitis, the use of plasma exchange did not reduce the incidence of death or ESKD. A reduced-dose regimen of glucocorticoids was noninferior to a standard-dose regimen with respect to death or ESKD. (Funded by the U.K. National Institute for Health Research and others; PEXIVAS Current Controlled Trials number, ISRCTN07757494; ClinicalTrials.gov number, NCT00987389.).